Signal and Data Processing
پردازش علائم و دادهها
JSDP
Engineering & Technology
http://jsdp.rcisp.ac.ir
1
admin
2538-4201
2538-421X
10.61882/jsdp
1
8888
fa
jalali
1397
6
1
gregorian
2018
9
1
15
2
online
1
fulltext
fa
الگوریتم بهینه تقسیمبندی تصاویر میکروسکوپی خون برای تشخیص سلولهای لوسمی حاد لنفوبلاست با استفاده از الگوریتم FCM و بهینهسازی ژنتیک
An Optimal Algorithm for Dividing Microscopic Images of Blood for the Diagnosis of Acute Pulmonary Lymphoblastic Cell Using the FCM Algorithm and Genetic Optimization
مقالات پردازش تصویر
Paper
پژوهشي
Research
<p dir="RTL" style="text-align: justify;"><strong><span style="color:black;"><span style="font-family:b nazanin;"><span style="font-size:10.0pt;">سرطان</span></span></span></strong><strong><span style="color:black;"><span style="font-family:b nazanin;"><span style="font-size:10.0pt;"></span></span></span></strong><strong><span style="color:black;"><span style="font-family:b nazanin;"><span style="font-size:10.0pt;">ها گروهی از بیماریها هستند که بهصورت رشد بیرویه و خارج از کنترل تعدادی از سلولها، ایجاد می­شوند و حدود دویست نوع مختلف دارند. سرطان لوسمی (خون) یکی از انواع این سرطانهاست. تشخیص</span></span></span></strong> <strong><span style="color:black;"><span style="font-family:b nazanin;"><span style="font-size:10.0pt;">سرطان</span></span></span></strong> <strong><span style="color:black;"><span style="font-family:b nazanin;"><span style="font-size:10.0pt;">خون</span></span></span></strong> <strong><span style="color:black;"><span style="font-family:b nazanin;"><span style="font-size:10.0pt;">در</span></span></span></strong> <strong><span style="color:black;"><span style="font-family:b nazanin;"><span style="font-size:10.0pt;">بیمارستانها</span></span></span></strong> <strong><span style="color:black;"><span style="font-family:b nazanin;"><span style="font-size:10.0pt;">و</span></span></span></strong> <strong><span style="color:black;"><span style="font-family:b nazanin;"><span style="font-size:10.0pt;">مراکز</span></span></span></strong> <strong><span style="color:black;"><span style="font-family:b nazanin;"><span style="font-size:10.0pt;">درمانی</span></span></span></strong> <strong><span style="color:black;"><span style="font-family:b nazanin;"><span style="font-size:10.0pt;">با</span></span></span></strong> <strong><span style="color:black;"><span style="font-family:b nazanin;"><span style="font-size:10.0pt;">تهیه</span></span></span></strong> <strong><span style="color:black;"><span style="font-family:b nazanin;"><span style="font-size:10.0pt;">لام</span></span></span></strong> <strong><span style="color:black;"><span style="font-family:b nazanin;"><span style="font-size:10.0pt;">از</span></span></span></strong> <strong><span style="color:black;"><span style="font-family:b nazanin;"><span style="font-size:10.0pt;">بافت خون</span></span></span></strong> <strong><span style="color:black;"><span style="font-family:b nazanin;"><span style="font-size:10.0pt;">و</span></span></span></strong> <strong><span style="color:black;"><span style="font-family:b nazanin;"><span style="font-size:10.0pt;">قراردادن</span></span></span></strong> <strong><span style="color:black;"><span style="font-family:b nazanin;"><span style="font-size:10.0pt;">زیر</span></span></span></strong> <strong><span style="color:black;"><span style="font-family:b nazanin;"><span style="font-size:10.0pt;">میکروسکوپ</span></span></span></strong> <strong><span style="color:black;"><span style="font-family:b nazanin;"><span style="font-size:10.0pt;">و توسط</span></span></span></strong> <strong><span style="color:black;"><span style="font-family:b nazanin;"><span style="font-size:10.0pt;">یک متخصص</span></span></span></strong> <strong><span style="color:black;"><span style="font-family:b nazanin;"><span style="font-size:10.0pt;">پاتولوژی</span></span></span></strong> <strong><span style="color:black;"><span style="font-family:b nazanin;"><span style="font-size:10.0pt;">صورت</span></span></span></strong> <strong><span style="color:black;"><span style="font-family:b nazanin;"><span style="font-size:10.0pt;">میگیرد.</span></span></span></strong> <strong><span style="color:black;"><span style="font-family:b nazanin;"><span style="font-size:10.0pt;">پاتولوژیستها</span></span></span></strong> <strong><span style="color:black;"><span style="font-family:b nazanin;"><span style="font-size:10.0pt;">با</span></span></span></strong> <strong><span style="color:black;"><span style="font-family:b nazanin;"><span style="font-size:10.0pt;">توجه</span></span></span></strong> <strong><span style="color:black;"><span style="font-family:b nazanin;"><span style="font-size:10.0pt;">به</span></span></span></strong> <strong><span style="color:black;"><span style="font-family:b nazanin;"><span style="font-size:10.0pt;">شکل</span></span></span></strong> <strong><span style="color:black;"><span style="font-family:b nazanin;"><span style="font-size:10.0pt;">و</span></span></span></strong> <strong><span style="color:black;"><span style="font-family:b nazanin;"><span style="font-size:10.0pt;">تعداد گلبولهای</span></span></span></strong> <strong><span style="color:black;"><span style="font-family:b nazanin;"><span style="font-size:10.0pt;">موجود</span></span></span></strong> <strong><span style="color:black;"><span style="font-family:b nazanin;"><span style="font-size:10.0pt;">در</span></span></span></strong> <strong><span style="color:black;"><span style="font-family:b nazanin;"><span style="font-size:10.0pt;">خون</span></span></span></strong> <strong><span style="color:black;"><span style="font-family:b nazanin;"><span style="font-size:10.0pt;">نوع</span></span></span></strong> <strong><span style="color:black;"><span style="font-family:b nazanin;"><span style="font-size:10.0pt;">بیماری</span></span></span></strong> <strong><span style="color:black;"><span style="font-family:b nazanin;"><span style="font-size:10.0pt;">را</span></span></span></strong> <strong><span style="color:black;"><span style="font-family:b nazanin;"><span style="font-size:10.0pt;">مشخص</span></span></span></strong> <strong><span style="color:black;"><span style="font-family:b nazanin;"><span style="font-size:10.0pt;">میکنند</span></span></span></strong><strong><span dir="LTR"><span style="color:black;"><span style="font-family:times new roman bold;"><span style="font-size:8.0pt;">.</span></span></span></span></strong><strong><span style="color:black;"><span style="font-family:b nazanin;"><span style="font-size:10.0pt;"> هدف از این مقاله ارائه مدلی هوشمند با</span></span></span></strong> <strong><span style="color:black;"><span style="font-family:b nazanin;"><span style="font-size:10.0pt;">استفاده</span></span></span></strong> <strong><span style="color:black;"><span style="font-family:b nazanin;"><span style="font-size:10.0pt;">از الگوریتم</span></span></span></strong> <strong><span dir="LTR"><span style="color:black;"><span style="font-family:times new roman bold;"><span style="font-size:8.0pt;">FCM</span></span></span></span></strong> <a href="#_ftn1" name="_ftnref1" title=""><strong><span dir="LTR"><span style="color:black;"><span style="font-family:times new roman bold;"><span style="font-size:8.0pt;"><strong><span style="color:black;"><span style="font-family:times new roman bold;"><span style="font-size:8.0pt;">[1]</span></span></span></strong></span></span></span></span></strong></a><strong><span style="color:black;"><span style="font-family:b nazanin;"><span style="font-size:10.0pt;"> بهمنظور خوشهبندی و شبکه عصبی برای انتخاب ویژگیهاست؛ همچنین در آن از الگوریتم ژنتیک در مرحله بهبود الگوهای</span></span></span></strong> <strong><span style="color:black;"><span style="font-family:b nazanin;"><span style="font-size:10.0pt;">تشخیصی استفاده شده است. با استفاده از این مدل به</span></span></span></strong> <strong><span style="color:black;"><span style="font-family:b nazanin;"><span style="font-size:10.0pt;">تشخیص زودهنگام سرطان</span></span></span></strong> <strong><span style="color:black;"><span style="font-family:b nazanin;"><span style="font-size:10.0pt;"> لوسمی حاد لنفوبلاست و سپس دستهبندی </span></span></span></strong><strong><span dir="LTR"><span style="color:black;"><span style="font-family:times new roman bold;"><span style="font-size:8.0pt;">ALL</span></span></span></span></strong><a href="#_ftn2" name="_ftnref2" title=""><strong><span style="color:black;"><span style="font-family:b nazanin;"><span style="font-size:10.0pt;"><span dir="LTR"><strong><span style="color:black;"><span style="font-family:times new roman bold;"><span style="font-size:8.0pt;">[2]</span></span></span></strong></span></span></span></span></strong></a><strong><span style="color:black;"><span style="font-family:b nazanin;"><span style="font-size:10.0pt;"> به سه زیر شاخه مورفولوژیکی (</span></span></span></strong><strong><span dir="LTR"><span style="color:black;"><span style="font-family:times new roman bold;"><span style="font-size:8.0pt;">L1</span></span></span></span></strong><strong><span style="color:black;"><span style="font-family:b nazanin;"><span style="font-size:10.0pt;">، </span></span></span></strong><strong><span dir="LTR"><span style="color:black;"><span style="font-family:times new roman bold;"><span style="font-size:8.0pt;">L2</span></span></span></span></strong><strong><span style="color:black;"><span style="font-family:b nazanin;"><span style="font-size:10.0pt;"> و</span></span></span></strong><strong><span dir="LTR"><span style="color:black;"><span style="font-family:times new roman bold;"><span style="font-size:8.0pt;">L3</span></span></span></span></strong><strong><span style="color:black;"><span style="font-family:b nazanin;"><span style="font-size:10.0pt;">) میتوان اقدام کرد. در</span></span></span></strong> <strong><span style="color:black;"><span style="font-family:b nazanin;"><span style="font-size:10.0pt;">این</span></span></span></strong> <strong><span style="color:black;"><span style="font-family:b nazanin;"><span style="font-size:10.0pt;">پژوهش</span></span></span></strong> <strong><span style="color:black;"><span style="font-family:b nazanin;"><span style="font-size:10.0pt;">نمونههایی</span></span></span></strong> <strong><span style="color:black;"><span style="font-family:b nazanin;"><span style="font-size:10.0pt;">از 38 بیمار</span></span></span></strong> <strong><span style="color:black;"><span style="font-family:b nazanin;"><span style="font-size:10.0pt;">سرطانی لوسمی</span></span></span></strong> <strong><span style="color:black;"><span style="font-family:b nazanin;"><span style="font-size:10.0pt;">حاد</span></span></span></strong> <strong><span style="color:black;"><span style="font-family:b nazanin;"><span style="font-size:10.0pt;">لنفوییدی</span></span></span></strong> <strong><span style="color:black;"><span style="font-family:b nazanin;"><span style="font-size:10.0pt;">تهیه</span></span></span></strong> <strong><span style="color:black;"><span style="font-family:b nazanin;"><span style="font-size:10.0pt;">شد</span></span></span></strong><strong><span dir="LTR"><span style="color:black;"><span style="font-family:times new roman bold;"><span style="font-size:8.0pt;">.</span></span></span></span></strong><strong><span style="color:black;"><span style="font-family:b nazanin;"><span style="font-size:10.0pt;"> این مطالعه بر روی 68 تصویر میکروسکوپی و با درنظرگرفتن پانزده ویژگی هندسی و آماری انجام شد که نتیجه آن حاکی از حساسیت، ویژگی و دقت بالاتر برای ده ویژگی نسبت به سایر ویژگیها بود. بر اساس ویژگیهای استخراجشده، این روش با سه روش مشابه اخیر مقایسه شد. ارزیابیها نشان داد که روش پیشنهادی بهطور میانگین پارامترهای حساسیت، ویژگی و دقت را به میزان 15/85%، 17/98% و 53/96% بهدست آورد. </span></span></span></strong></p>
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<div id="ftn1" style="text-align: justify;"> <span dir="RTL"><span style="font-family:b nazanin;"><span style="font-size:11.0pt;"> </span></span></span> <span dir="RTL"></span></div>
<div id="ftn2" style="text-align: justify;">1 Fuzzy C-means Clustering <br>
2 Acute Lymphoblastic Leukemia </div>
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<strong>Cancer is type of disease caused by irregular, uncontrollable growth of blood cells in bone marrow. The process of generating three main blood cells including pallets, red and white blood cells, is started from a progenitor cell called as blast. Blast generates a considerable number of immature cells which are developed affected by differentiation factors. If any interruption occurs during this process, leukemia may be initiated. </strong>
<strong>Diagnosis of leukemia is performed at hospitals or medical centers by examination of the blood tissue smeared across a slide and under a microscope by a pathologist. Processing the digital images of blood cells, in order to improve the quality of the image or highlighting the malicious segments of the image, is important in early stages of the disease. </strong>
<strong>There are four types of leukemia consisting acute or chronic and myeloid or lymphocytic. Acute lymphocytic (or lymphoblastic) leukemia (ALL) is concentrated in this study. ALL is caused by continuous generation of immature, malignant lymphocytes in bone marrow which are speeded by blood circulation to other organs. </strong>
<strong>In this research, fuzzy C-means (FCM) algorithm is applied to blood digital images for clustering purpose, neural networks for feature selection and Genetic Algorithm (GA) for optimization. This model diagnoses ALL at early stages and categorizes it into three morphological subcategories (i.e., L1, L2, and L3).</strong>
<strong>For performance evaluation of the proposed method, 38 samples of patients with ALL were collected. It was performed on 68 microscopic images in terms of 15 features and yielded to higher percentage of sensitivity, specificity, and accuracy for 10 out of 15 features. The proposed method was compared to three recent methods. The evaluations showed that the sensitivity, specificity and accuracy reached to 85.15%, 98.17% and 96.53%, respectively. </strong>
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سرطان خون, الگوریتم FCM, شبکه عصبی, الگوریتم ژنتیک, خوشهبندی
leukemia, FCM algorithm, neural network, genetic algorithm, clustering
45
54
http://jsdp.rcisp.ac.ir/browse.php?a_code=A-10-883-3&slc_lang=fa&sid=1
Abbas
Karimi
عباس
کریمی
akarimi@iau-arak.ac.ir
10031947532846006284
10031947532846006284
Yes
Arak Branch, Islamic Azad UNiversity
دانشگاه آزاد اسلامی اراک
Leila Sadat
Hoseini
لیلا سادات
حسینی
rahenorayaneh@yahoo.com
10031947532846006285
10031947532846006285
No
Arak Branch, Islamic Azad UNiversity
دانشگاه آزاد اسلامی اراک